Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNFRSF11A |
| Gene Name: | TNFRSF11A |
| Protein Full Name: | Tumor necrosis factor receptor superfamily member |
| Alias: | CD265; ODFR; OFE; osteoclast differentiation factor receptor; RANK; receptor activator of NF-KB; TNR11; TRANCER; tumor necrosis factor receptor superfamily member 11A; tumor necrosis factor receptor superfamily, member 11a, NFKB activator |
| Mass (Da): | 66030 |
| Number AA: | 616 |
| UniProt ID: | Q9Y6Q6 |
| Locus ID: | 8792 |
| COSMIC ID: | TNFRSF11A |
| Gene location on chromosome: | 18q21.33 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20151 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | This protein member of the tumor-necrosis factor receptor superfamily but is known mainly by the name RANK and is involved in the TNFSF11/RANKL/TRANCE/OPGL complex in bone; essential for RANKL-mediated osteoclastogenesis. Defects in this gene have been implicated in bone mineral diseases but role in cancer remains unclear. Given its described activation of NF-kB signalling it is possible that TNFRSF6B can promote oncogensis through this pathway. |