Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NCOR2 |
| Protein Full Name: | Nuclear receptor co-repressor 2 isoform 1 |
| Mass (Da): | 274730 |
| UniProt ID: | Q9Y618 |
| Locus ID: | 9612 |
| Gene location on chromosome: | 12q24 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 1.85 |
| Normal role description: | NCOR2 is a nuclear receptor co-repressor (NCOR) that mediates transcriptional silencing of NR4A2/NURR1. It acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Mutations in this gene have been found in ovarian, skin, and stomach tumors. Since mutations in this gene could lead to increase or decreased repression of either poto-oncogenes or tumour suppressor genes, it role in oncogenesis, if any, is unclear. |
| Commentary on involvement of protein in cancer: | Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state By similarity. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform1 and isoform 5 have different affinities for different nuclear receptors. |