Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CARD8 |
| Gene Name: | CARD8 |
| Alias: | Apoptotic protein NDPP1;CARD-inhibitor of NF-kappa-B-activating ligand;DACAR;Tumor up-regulated CARD-containing antagonist of CASP9 |
| Mass (Da): | 48933 |
| Number AA: | 431 |
| UniProt ID: | Q9Y2G2 |
| Locus ID: | 22900 |
| COSMIC ID: | CARD8 |
| Gene location on chromosome: | 19q13.32 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 0.35 |
| Normal role description: | Involved in apoptosis signalling. Expressed in many different tissues in the body. CARD8 been shown to both recruit the formation of the apoptosome and also inhibit apoptasome formation depending on the cell system. This variability may be mediated by other domains which confer protein-interaction specificity. |