Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TBK1 |
| Gene Name: | TBK1 |
| Protein Full Name: | Serine/threonine-protein kinase TBK1 |
| Alias: | EC 2.7.11.1; Kinase TBK1; NAK; NF-KB-activating kinase NAK; TANK binding kinase TBK1; TANK-binding kinase 1 |
| Mass (Da): | 83642 |
| Number AA: | 729 |
| UniProt ID: | Q9UHD2 |
| Locus ID: | 29110 |
| COSMIC ID: | TBK1 |
| Gene location on chromosome: | 12q14.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19967 |
| Percent of cancer specimens with mutations: | 0.52 |
| Commonly recorded point mutations: | E109K (10) |
| Normal role description: | Protein kinase. |