Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LIMA1 |
| Gene Name: | LIMA1 |
| Protein Full Name: | ISOFORM BETA OF LIM DOMAIN AND ACTIN-BINDING PROTE |
| Alias: | Epithelial protein lost in neoplasm |
| Mass (Da): | 85226 |
| Number AA: | 759 |
| UniProt ID: | Q9UHB6 |
| Locus ID: | 51474 |
| COSMIC ID: | LIMA1 |
| Gene location on chromosome: | 12q13 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.6 |
| Commentary on involvement of protein in cancer: | Binds to actin monomers and filaments. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments. |