Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PPP1R1B |
| Gene Name: | PPP1R1B |
| Protein Full Name: | Dopamine- and cAMP-regulated neuronal phosphoprote |
| Alias: | Dopamine and cAMP regulated phosphoprotein; Dopamine- and cAMP-regulated neuronal phosphoprotein; FLJ20940; IPPD; Neuronal phosphoprotein DARPP-32; PPP1R1B; PPR1B; Protein phosphatase 1, regulatory (inhibitor) subunit 1B |
| Mass (Da): | 22963 |
| Number AA: | 204 |
| UniProt ID: | Q9UD71 |
| Locus ID: | 84152 |
| COSMIC ID: | PPP1R1B |
| Gene location on chromosome: | 17q12 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.17 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | PPP1R1B is a protein serine/threonine phosphatase regulatory protein that specifically inhibits protein-phosphatase 1. It has been shown to be overexpressed in gastric cancers, thus the suggestion that PPP1R1B provides an important survival advantage to neoplastic cells. It may confer anti-apoptotic function by increasing Bcl-2 expression levels. |