Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TMPRSS4 |
| Gene Name: | TMPRSS4 |
| Protein Full Name: | Transmembrane protease serine 4 |
| Alias: | Channel-activating protease 2;Membrane-type serine protease 2 |
| Mass (Da): | 48204 |
| Number AA: | 437 |
| UniProt ID: | Q9NRS4 |
| Locus ID: | 56649 |
| COSMIC ID: | TMPRSS4 |
| Gene location on chromosome: | 11q23.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19628 |
| Percent of cancer specimens with mutations: | 0.44 |
| Normal role description: | TMPRSS4 is a membrane-bound serine protease implicated in oncogenesis and tumour metastasis. Induction of TMPRSS4 caused loss of E-cadherin in the SW480 cell line as well as metastasis. TMPRSS4 is upregulated in many different cancer systems. TMPRSS4 may overcome the need for contact-dependent growth in tumour cells by circumventing the cadherin signalling pathway |