Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BIRC6 |
| Gene Name: | BIRC6 |
| Protein Full Name: | Baculoviral IAP repeat-containing protein 6 |
| Alias: | Apollon; Baculoviral IAP repeat-containing 6; BIR6; BRUCE; KIAA1289; Ubiquitin carrier protein; Ubiquitin-conjugating BIR domain enzyme apollon; Ubiquitin-conjugating BIR-domain enzyme apollon; Ubiquitin-conjugating enzyme E2; Ubiquitin-protein ligase |
| Mass (Da): | 527610 |
| Number AA: | 4829 |
| UniProt ID: | Q9NR09 |
| Locus ID: | 57448 |
| COSMIC ID: | BIRC6 |
| Gene location on chromosome: | 2p22 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19806 |
| Percent of cancer specimens with mutations: | 2.78 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations and 1 deletion , but no complex mutations or insertions. |
| Normal role description: | Inhibitor of apoptosis protein. Binds and inhibits activated caspases. Acts as a chimeric E2/E3 ubiquitin ligase and ubiquitylates caspase-9, HtrA2 (a pro-apoptotic serine protease) and DIABLO/Smac. Protects cells from apoptosis. Overexpression found in several cancer cell lines. |