Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RTN4 |
| Gene Name: | RTN4 |
| Protein Full Name: | Reticulon-4 |
| Alias: | ASY; Foocen; KIAA0886; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NOGO; Nogo protein; NSP; NSP-CL; Reticulon 4; Reticulon-4; Reticulon-5; RTN-x |
| Mass (Da): | 129931 |
| Number AA: | 1192 |
| UniProt ID: | Q9NQC3 |
| Locus ID: | 57142 |
| COSMIC ID: | RTN4 |
| Gene location on chromosome: | 2p16.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.67 |
| Normal role description: | RTN4 functions as negative regulator of axon-axon adhesion and growth. Its also regulates neurite fasciculation, branching, and extension in the developing nervous system. One of RTN4 isoforms reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. Overexpression of this gene has been implicated in inducing apoptosis. Mutations in this gene are associated with a variety of cancers. Downregulation of RTN4 has been observed in lung and blood cancers, while upregulation has been seen in astrocytomas. Knocking out this gene in mice results in increased tumour foration. |