Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LGR6 |
| Gene Name: | LGR6 |
| Protein Full Name: | Leucine-rich repeat-containing G-protein coupled r |
| Alias: | Gonadotropin receptor; VTS20631 |
| Mass (Da): | 104298 |
| Number AA: | 967 |
| UniProt ID: | Q9HBX8 |
| Locus ID: | 59352 |
| COSMIC ID: | LGR6 |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19712 |
| Percent of cancer specimens with mutations: | 0.91 |
| Normal role description: | Adult Lgr6-positive cells executed long-term wound repair, including the formation of new hair follicles. Snippert et al. (2010) concluded that LGR6 marks the most primitive epidermal stem cell. Role in oncogenesis may be mediated by de-differentiation and immortalization. |