Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PTPN18 |
| Gene Name: | PTPN18 |
| Protein Full Name: | Tyrosine-protein phosphatase non-receptor type 18 |
| Alias: | Brain-derived phosphatase; EC 3.1.3.48; Fetal liver phosphatase 1; FLP1; HSCF; Protein tyrosine phosphatase 20; Protein tyrosine phosphatase, non-receptor type 18 (brain-derived); Protein-tyrosine phosphatase 18; Protein-tyrosine phosphatase, non-receptor type 18; PTN18; PTNI; PTP 49; PTP HSCF; PTP20; PTPK1; PTP-K1; PTPN18 |
| Mass (Da): | 50482 |
| Number AA: | 460 |
| UniProt ID: | Q99952 |
| Locus ID: | 26469 |
| COSMIC ID: | PTPN18 |
| Gene location on chromosome: | 2q21.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.35 |
| Normal role description: | PTPN18 is a protein-tyrosine phosphatase that function as asignalling molecule responsible for regulating a number of cellular processes such as cell growth and differentiation. It contains a PEST motif, responsible for protein-protein interactions. PTPN18 can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumours, and it may play a role in regulation of HER2. |
| Commentary on involvement of protein in cancer: | 1/101 kidney samples was also mutated (Sanger COSMIC) |