Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: UHRF1
Gene Name: UHRF1
Protein Full Name: Ubiquitin-like with PHD and ring finger domains 1
Mass (Da): 91116
Number AA: 806
UniProt ID: Q96T88
Locus ID: 29128
COSMIC ID: UHRF1
Gene location on chromosome: 19p13.3
Cancer protein type: UNCLEAR
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: UNCLEAR
Number of cancer specimens: 20061
Percent of cancer specimens with mutations: 0.46
Normal role description: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. However, UHRF1 is up-regulated in proliferating cells, and down-regulated in quiescent cells which may imply it facilitates cell cylcle progression rather than inhibiting it. Thus, its role in oncogenesis remains unclear and it may function as both an oncogene or TSP.


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