Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CSRNP1 |
| Gene Name: | CSRNP1 |
| Protein Full Name: | Cysteine/serine-rich nuclear protein 1 |
| Alias: | Axin-1 up-regulated gene 1 protein;Protein URAX1;TGF-beta-induced apoptosis protein 3 |
| Mass (Da): | 63522 |
| Number AA: | 589 |
| UniProt ID: | Q96S65 |
| Locus ID: | 64651 |
| COSMIC ID: | CSRNP1 |
| Gene location on chromosome: | 3p2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | This protein binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity; its is induced in response to elevated levels of axin -- a tumour suppressor. CSRNP1 may also have tumour suppressor activity. Mutation in this gene have been associated with ovarian and skin cancer. |
| Commentary on involvement of protein in cancer: | Binds to the consensus sequence 5'-AGAGTG-3' and has transcriptional activator activity By similarity. May have a tumor-suppressor function. May play a role in apoptosis. Frequently down-regulated in lung, kidney, liver and colon cancers compared with their corresponding normal tissues. |