Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GSDMA |
| Gene Name: | GSDMA |
| Protein Full Name: | Gasdermin-A |
| Alias: | Gasdermin family member A; GSDM; GSDM1 |
| Mass (Da): | 49379 |
| Number AA: | 445 |
| UniProt ID: | Q96QA5 |
| Locus ID: | 284110 |
| COSMIC ID: | GSDMA |
| Gene location on chromosome: | 17q21.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.36 |
| Normal role description: | Induces apoptosis. Details unknown. Frequently silenced in gastric and esophageal cancer. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the Atlas of Genetics in Oncology or the SANGER COSMIC database. |