Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTHRC1 |
| Gene Name: | CTHRC1 |
| Protein Full Name: | Collagen triple helix repeat-containing protein 1 |
| Alias: | Protein NMTC1 |
| Mass (Da): | 26224 |
| Number AA: | 243 |
| UniProt ID: | Q96CG8 |
| Locus ID: | 115908 |
| COSMIC ID: | CTHRC1 |
| Gene location on chromosome: | 8q22.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | CTHRC1 is a cell adhesion regulator and a negative regulator of collagen matrix deposition. It is specifically expressed in vascular calcifications of carotid artery lesions and may play a role in vascular remodelling of injured arteries. It also functions as an inhibitor of TGF-β signalling and may play a role in the Planar Cell Polarity (PCP) pathway of non-canonical Wnt signalling, possibly by interaction with, and stabilization of, several of the Frizzled receptors on the cell surface. It is overexpressed in many human solid cancers. |
| Commentary on involvement of protein in cancer: | Only 1 ovarian tumour sample was included in Sanger COSMIC. |