Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | COPS5 |
| Gene Name: | COPS5 |
| Protein Full Name: | COP9 signalosome complex subunit 5 |
| Alias: | 38 kDa Mov34; COP9 constitutive photomorphogenic subunit 5; COP9 signalosome complex 5; CSN5; JAB1; Jun activation domain-binding; Jun activation domain-binding 1; MOV-34; SGN5; signalosome 5 |
| Mass (Da): | 37579 |
| Number AA: | 334 |
| UniProt ID: | Q92905 |
| Locus ID: | 10987 |
| COSMIC ID: | COPS5 |
| Gene location on chromosome: | 8q13.1 |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.28 |
| Commentary on involvement of protein in cancer: | Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. |