Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ELMO1 |
| Gene Name: | ELMO1 |
| Protein Full Name: | Engulfment and cell motility protein 1 |
| Alias: | CED12; CED-12; CED-12 homolog; ELM1; ELMO-1; Engulfment and cell motility 1; KIAA0281 |
| Mass (Da): | 83829 |
| Number AA: | 727 |
| UniProt ID: | Q92556 |
| Locus ID: | 9844 |
| COSMIC ID: | ELMO1 |
| Gene location on chromosome: | 7p14.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19650 |
| Percent of cancer specimens with mutations: | 1.33 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ELMO1 is an evolutionarily conserved protein involved in the phagocytosis of apoptotic cells and cell motility through cytoskeletal rearrangements. Other functions may include activation of Rac/Rho GTPases and/or enhancement of DOCK1, a guanine nucleotide exchange factor. Increased expression of this gene has been found to promote glioma cell invasion. |
| Commentary on involvement of protein in cancer: | no entry in AGO |