Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUP133 |
| Gene Name: | NUP133 |
| Protein Full Name: | Nucleoporin 133kDa |
| Mass (Da): | 23833 |
| Number AA: | 224 |
| UniProt ID: | Q8WUM0 |
| Locus ID: | 55746 |
| COSMIC ID: | NUP133 |
| Gene location on chromosome: | 1q42.13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19758 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | NUP133 is component of the nuclear pore complex which regulates the import and export of macromolecules between the cytoplasm and nucleus. More specifically, NUP133 is a component of the NUP160 subcomplex which may have a role in mRNA export from the nucleus. Several mutations of NUP133 have been detected in cancers but their functional role has not been characterized. Due to NUP133's role in regulating mRNA export dysfunction in this gene may contribute to aberrant translation of nascent mRNA. |