Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | FAT3 |
| Protein Full Name: | Rab11 family-interacting protein 5 |
| Alias: | PTMS-related |
| Mass (Da): | 507119 |
| UniProt ID: | Q8TDW7 |
| Locus ID: | 120114 |
| Gene location on chromosome: | 11q14.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19700 |
| Percent of cancer specimens with mutations: | 1.7 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many several mutations, but no complex, insertion or deletion mutants. |
| Normal role description: | FAT3 is a single-pass type I membrane protein that may play a role in neurite interaction during development. |
| Commentary on involvement of protein in cancer: | * 2/2 laryngeal samples were also mutated (mis-sense & silent) |