Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRPV1 |
| Gene Name: | TRPV1 |
| Protein Full Name: | Transient receptor potential cation channel subfam |
| Alias: | Capsaicin receptor; Transient receptor cation channel V1; Transient receptor potential cation channel, subfamily V, member 1; TRPV1; Vanilloid receptor 1 |
| Mass (Da): | 94938 |
| Number AA: | 839 |
| UniProt ID: | Q8NER1 |
| Locus ID: | 7442 |
| COSMIC ID: | TRPV1 |
| Gene location on chromosome: | 17p13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19557 |
| Percent of cancer specimens with mutations: | 0.56 |
| Normal role description: | TRPV1 is a cation channel that opens in response to its ligand, capsaisin, as well as noxious temperatures.TRPV1 may play a role in mediating of inflammatory pain and hyperalgesia. Upregulation of this gene has been observed in bone, brain, cervical, liver, pancreatic, and prostate tumors. |