Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DRAM1 |
| Gene Name: | DRAM1 |
| Protein Full Name: | DNA damage-regulated autophagy modulator protein 1 |
| Alias: | Damage-regulated autophagy modulator |
| Mass (Da): | 26253 |
| Number AA: | 238 |
| UniProt ID: | Q8N682 |
| Locus ID: | 55332 |
| COSMIC ID: | DRAM1 |
| Gene location on chromosome: | 12q23.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.24 |
| Normal role description: | Encodes for a lysosomal membrane protein, that modulates TP53 induced apoptosis and is involved in TP53 mediated autophagy. Decreased expression is associated with various types of tumors. Suggested to act as a tumour suppressor downstream of p53. However the precise function is unknown. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the Atlas of Genetics in Oncology. Only one mutated sample described in the SANGER COSMIC database. |