Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ASPM |
| Gene Name: | ASPM |
| Protein Full Name: | Abnormal spindle-like microcephaly associated spli |
| Alias: | Abnormal spindle protein homologue; Abnormal spindle-like microcephaly-associated protein |
| Mass (Da): | 164930 |
| Number AA: | 1389 |
| UniProt ID: | Q8IZT6 |
| Locus ID: | 259266 |
| COSMIC ID: | ASPM |
| Gene location on chromosome: | 1q31.3 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19719 |
| Percent of cancer specimens with mutations: | 2.67 |
| Normal role description: | ASPM is a component of the spindles formed in mitosis and regulates the orientation of the cleavage plane. It has a preferential role in neurogenesis and is critical for expansion of the cerebral cortex. Overexpression of this gene is seen in cancers. |