Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NUT |
| Gene Name: | NUT |
| Protein Full Name: | Protein NUT |
| Alias: | Nuclear protein in testis |
| Mass (Da): | 120330 |
| Number AA: | 1132 |
| UniProt ID: | Q86Y26 |
| Locus ID: | 256646 |
| COSMIC ID: | NUT |
| Gene location on chromosome: | 15q14 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 207 |
| Percent of cancer specimens with mutations: | 1.9323671498 |
| Deregulated in translocations: | Carcinoma with t(15;19)(q14;p13) translocations have been founds; this translocation creates a BRD4-NUT chimeric protein. |
| Normal role description: | NUT is a nuclear protein that is localized to the testis, though its function is currently unknown. Mutations in this gene have been found in ovarian and skin tumors, while translocation of this gene, t(15;19)(q14;p13), is implicated in promoting carcinoma formation in midline oragans, by causing aberrant regulation of NUT via BRD4 promoter elements and thereby leading to ectopic expression. |