Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ANKS1B |
| Gene Name: | ANKS1B |
| Protein Full Name: | Ankyrin repeat and sterile alpha motif domain-cont |
| Alias: | AIDA-1; Amyloid-beta protein intracellular domain-associated protein 1; ANKS1B; ANKS2; Ankyrin repeat and sterile alpha motif domain containing 1B; Cajalin-2; E2A-PBX1-associated protein; EB-1 |
| Mass (Da): | 138185 |
| Number AA: | 1249 |
| UniProt ID: | Q7Z6G8 |
| Locus ID: | 56899 |
| COSMIC ID: | ANKS1B |
| Gene location on chromosome: | 12q23.1 |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 1.31 |
| Deregulated in translocations: | t(1;19) |
| Normal role description: | t(1:19) translocation in pre-B ALL causes the chimeric oncoprotein E2A/PBX1 leading to downstreat overexpression of the ANKS1B gene. However, the exact role of ANKS1B is unclear - |