Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RbBP6 |
| Gene Name: | RBBP6 |
| Protein Full Name: | E3 ubiquitin-protein ligase RBBP6 |
| Alias: | My038; P2PR; P53-associated cellular protein of testis; PACT; RBQ1 |
| Mass (Da): | 201564 |
| Number AA: | 1792 |
| UniProt ID: | Q7Z6E9 |
| Locus ID: | 5930 |
| COSMIC ID: | RBBP6 |
| Gene location on chromosome: | 16p12.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 1.4 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | RBBP6 is a E3 ubiquitin-protein ligase that ubiquitinates YBX1, a putative anti-metastatic protein, and targets it for degradation by the proteasome. It may also be a negative regulator of p53/TP53 by acting as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, which would increase MDM2-mediated ubiquination and degradation of p53. This would promote cell proliferation and tumour growth. |