Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CREB3L2 |
| Gene Name: | CREB3L2 |
| Protein Full Name: | Cyclic AMP-responsive element-binding protein 3-li |
| Alias: | BBF2 human homologue on chromosome 7; BBF2H7; CR3L2 |
| Mass (Da): | 57429 |
| Number AA: | 520 |
| UniProt ID: | Q70SY1 |
| Locus ID: | 64764 |
| COSMIC ID: | CREB3L2 |
| Gene location on chromosome: | 7q34 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19834 |
| Percent of cancer specimens with mutations: | 0.45 |
| Deregulated in translocations: | t(7;16)(q33-34;p11); FUS/CREB3L2; fibrosarcoma |
| Normal role description: | CREB3L2 mediates late ER stress response and upregulates gene transcription via the CRE DNA element. Oncogenesis occurs via fusion protein; b-ZIP domain of CREB3L2 is now under control of FUS promoter. B-zip transcription factor targets become disregulated. |