Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: C10orf137
Gene Name: EDRF1
Protein Full Name: Erythroid differentiation-related factor 1
Alias: chromosome 10 open reading frame 137; DKFZp586F1019; EDRF1; FLJ21617
Mass (Da): 138530
Number AA: 1238
UniProt ID: Q3B7T1
Locus ID: 26098
COSMIC ID: EDRF1
Gene location on chromosome: 10q26.13-q26.2
Cancer protein type: UNCLEAR
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: UNCLEAR
Number of cancer specimens: 20210
Percent of cancer specimens with mutations: 0.92
Mutations observed as inherited: NA
Found in amplified chromosomal regions in human cancers: NA
Deregulated in translocations: NA
Deregulated by viral insertion: NA
Transduced into viral genome: NA
Gene undergoes hypermethylation: NA
Normal role description: The C10orf137 encodes a transcription factor involved in the activation of the globin gene in erythrocyte differentiation. Certain missense mutations have been associated with colorectal cancer, such as N45S and L95F.
Commentary on involvement of protein in cancer: no entry in AGO


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