Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DDR2 |
| Gene Name: | DDR2 |
| Protein Full Name: | Discoidin domain-containing receptor 2 |
| Alias: | Discoidin domain receptor 2; Discoidin domain receptor tyrosine kinase 2; EC 2.7.1.112; EC 2.7.10.1; Neurotrophic tyrosine kinase, receptor-related 3; NTRKR3; Receptor protein-tyrosine kinase TKT; TKT; TYRO10; Tyrosine-protein kinase TYRO 10 |
| Mass (Da): | 96736 |
| Number AA: | 855 |
| UniProt ID: | Q16832 |
| Locus ID: | 4921 |
| COSMIC ID: | DDR2 |
| Gene location on chromosome: | 1q23.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20794 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | DDR2 is a receptor-tyrosine kinase most closely realted to the neurotrophin receptor family, Trks. DDR2 is highly expressed along chondrocyte columns in the growth plate of mice and may have a role in regulating growth and development. A mis-sense mutation has been detected in lung large cell carcinoma, although the exact role DDR2 has in cancer development is unknown. |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in CNS, kidney, lung and ovary. |