Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAPK14 |
| Gene Name: | MAPK14 |
| Protein Full Name: | Mitogen-activated protein kinase 14 |
| Alias: | CRK1; CSAID binding protein; CSBP; CSBP1; CSBP2; CSPB1; Cytokine suppressive anti-inflammatory drug binding protein; EC 2.7.11.24; Kinase p38-alpha; MAP kinase MXI2; MAP kinase p38; MAPK14; MAX-interacting protein 2; Mitogen-activated protein kinase p38; MK14; MXI2; P38; P38 MAP kinase; P38 MAPK-alpha; PRKM14; PRKM15 |
| Mass (Da): | 41293 |
| Number AA: | 360 |
| UniProt ID: | Q16539 |
| Locus ID: | 1432 |
| COSMIC ID: | MAPK14 |
| Gene location on chromosome: | 6p21.31 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20513 |
| Percent of cancer specimens with mutations: | 0.33 |
| Normal role description: | MAPK14 is a protein-serine/threonine kinase that is activated by pro-inflammatory cytokines, environmental stress and LPS, via phosphorylation by MAP kinase kinases, or autophosphorylation. Its substrates include the transcription regulators ATF2, MEF2C, and MAX; the cell cycle regulator CDC25B; and p53, which indicates that MAPK14 plays a role in stress-related transcription and in cell cycle regulation, as well as in the genotoxic stress response. It is a key player in the maintenance of hematopoiesis homeostasis, as it balances both proliferative and growth inhibitory signals from growth factors/cytokines that regulate hematopoiesis. Alterations in this controlled balance could result in either overproduction or depletion of myelosuppressive cytokines, which could lead to the development of various types of bone marrow failures. |
| Commentary on involvement of protein in cancer: | 1/74 gastric-, 1/477 CNS-, 1/359 lung-, and 2/86 ovarian cancer samples were also mutated (Sanger COSMIC) |