Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HLTF |
| Gene Name: | HLTF |
| Protein Full Name: | Helicase-like transcription factor |
| Alias: | DNA-binding protein/plasminogen activator inhibitor 1 regulator; EC=3.6.1.-; Helicase-like transcription factor; HIP116; HIP116A; HLTF1; RING finger protein 80; RNF80; SMARCA3; SNF2L3; Sucrose nonfermenting protein 2-like 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3; ZBU1 |
| Mass (Da): | 113929 |
| Number AA: | 1009 |
| UniProt ID: | Q14527 |
| Locus ID: | 6596 |
| COSMIC ID: | HLTF |
| Gene location on chromosome: | 3q24; 3q25.1-q26.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.69 |
| Gene undergoes hypermethylation: | Hypermethylation of promoter in colon cancer (43%), adenomas and hepatocarcinomas. |
| Normal role description: | HLTF is a transcription factor with ATP-dependent DNA helicase activity. HLTF is a member of the SWI/SNF chromatin remodeling family of enzymes and has a role in transcriptional activation or repression of target promoters. HLTF interacts with SP1 and SP3 transcription factors to facilitate transcription of target genes. HLTF also has E3 ubiquitin activity and has a role in DNA repair. HLTF expression is silenced by promoter hypermethylation in colon, gastric and uterine cancer. HLTF is classified as a tumour suppressor protein. |