Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | E2F2 |
| Gene Name: | E2F2 |
| Protein Full Name: | Transcription factor E2F2 |
| Alias: | E2F-2 |
| Mass (Da): | 47506 |
| Number AA: | 437 |
| UniProt ID: | Q14209 |
| Locus ID: | 1870 |
| COSMIC ID: | E2F2 |
| Gene location on chromosome: | 1p36 |
| Number of cancer specimens: | 19905 |
| Percent of cancer specimens with mutations: | 0.32 |
| Commentary on involvement of protein in cancer: | Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F-2 binds specifically to RB1 protein, in a cell-cycle dependent manner. |