Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IKBKE |
| Gene Name: | IKBKE |
| Protein Full Name: | Inhibitor of nuclear factor kappa-B kinase subunit |
| Alias: | EC 2.7.11.10; I kappa-B kinase epsilon; IkBKE; IKKE; IKKI; KIAA0151 |
| Mass (Da): | 80462 |
| Number AA: | 716 |
| UniProt ID: | Q14164 |
| Locus ID: | 9641 |
| COSMIC ID: | IKBKE |
| Gene location on chromosome: | 1q32.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20589 |
| Percent of cancer specimens with mutations: | 0.66 |
| Normal role description: | IKBKE is a protein-serine/threonine kinase. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Loss of function therefore blunts the NF-kB response. Cells with DNA damage are unable to undergo apoptosis. Oncogenesis may therefore occur indirectly by inhibitting a downstream tumour suppresor (inhibitors of NF-kB). |