Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NAE1 |
| Gene Name: | NAE1 |
| Protein Full Name: | NEDD8-activating enzyme E1 regulatory subunit |
| Alias: | Amyloid beta precursor protein-binding protein 1, 59 kDa; Amyloid protein-binding 1; APP-BP1; HPP1; NEDD8 activating enzyme E1 subunit 1; NEDD8-activating enzyme E1 subunit; Protooncogene protein 1; ULA1; Ula-1 |
| Mass (Da): | 60250 |
| Number AA: | 534 |
| UniProt ID: | Q13564 |
| Locus ID: | 8883 |
| COSMIC ID: | NAE1 |
| Gene location on chromosome: | 16q22 |
| Number of cancer specimens: | 19604 |
| Percent of cancer specimens with mutations: | 0.38 |
| Commentary on involvement of protein in cancer: | Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation. |