Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | EIF4EBP1 |
| Gene Name: | EIF4EBP1 |
| Protein Full Name: | Eukaryotic translation initiation factor 4E-bindin |
| Alias: | 4EBP1; EIF4EBP1; Eukaryotic translation initiation factor 4E binding protein 1; Insulin-stimulated EIF-4E binding protein PHAS-I; P,OKCL.6; P/OKCL.6; PHAS-1; PHAS-I; Phosphorylated heat- and acid-stable protein regulated by insulin 1 |
| Mass (Da): | 12450 |
| Number AA: | 118 |
| UniProt ID: | Q13541 |
| Locus ID: | 1978 |
| COSMIC ID: | EIF4EBP1 |
| Gene location on chromosome: | 8p12 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.07 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | EIF4EBP1 is a translation repressor protein that affects inhibits protein synthesis by regulating eIF4E activity and preventing its assembly into the eIF4F complex. Its actions are mediated by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. It's been found that overexpression of EIF4EBP1 could partially reverse v-src-transformed cells, suggesting its role as a negative regulator of cell growth. However, it has also been reported that many advanced breast cancers overexpress EIF4EBP1 and may be promoting tumour cell growth and survival by activating a hypoxia-activated switch in pro-oncogenic gene translation. |