Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STK3 |
| Gene Name: | STK3 |
| Protein Full Name: | Serine/threonine-protein kinase 3 |
| Alias: | EC 2.7.11.1; Krs-1; MESS1; Serine,threonine protein kinase 3; STK3 |
| Mass (Da): | 56301 |
| Number AA: | 491 |
| UniProt ID: | Q13188 |
| Locus ID: | 6788 |
| COSMIC ID: | STK3 |
| Gene location on chromosome: | 8q22.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20473 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | STK3 is a serine/threonine kinase that is induced by stress to carry out pro-apoptotic signalling. Once STK3 is activated by caspase-cleavage, it enters the nucleus where it then induces chromatin condensation followed by inter-nucleosomal DNA-fragmentation.STK3 also play a critical role in controlling organ size and tumors suppression by inhibiting proliferation and promoting apoptosis. Mutations in this gene have been observed in head and neck (pharynx) cancer. |