Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | REST |
| Gene Name: | REST |
| Protein Full Name: | RE1-silencing transcription factor |
| Alias: | Neural-restrictive silencer factor; NRSF; X2 box repressor; XBR |
| Mass (Da): | 121888 |
| Number AA: | 1097 |
| UniProt ID: | Q13127 |
| Locus ID: | 5978 |
| COSMIC ID: | REST |
| Gene location on chromosome: | 4q12 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19838 |
| Percent of cancer specimens with mutations: | 0.83 |
| Normal role description: | REST is a transcriptional repressor that acts to negatively regulate neuronal-genes in neuronal tissue. It is a member of the Kruppel-type zinc finger transcription factor family. REST-mediated inhibition is facilitated by REST binding to neuron-restrictive silencer element (NRSE). Missense mutations in this gene have been found in lung, mouth, and skin tumors. Additionally, deletions of the chromosome 4q12-region (where REST is located) are common in colon tumors. Downregulation of this gene is associate with lung and breast tumors, indicating a potential tumour supppressor capacity of normal REST. |