Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRDX1 |
| Gene Name: | PRDX1 |
| Protein Full Name: | Peroxiredoxin-1 |
| Alias: | Natural killer cell-enhancing factor A;Proliferation-associated gene protein;Thioredoxin peroxidase 2;Thioredoxin-dependent peroxide reductase 2 |
| Mass (Da): | 22110 |
| Number AA: | 199 |
| UniProt ID: | Q06830 |
| Locus ID: | 5052 |
| COSMIC ID: | PRDX1 |
| Gene location on chromosome: | 1p34.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19626 |
| Percent of cancer specimens with mutations: | 0.16 |
| Normal role description: | PRDX1 is involved in reduction of hydrogen peroxide and alkyl hydroperoxides. It may also be involved in cell proliferation pathways and regulation of postmitotic motor neuron differentiation. Loss of PRDX1 in mice leads to oncogenesis in many organs due to damage of hydrogen peroxides and other damaging agents. |