Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Tyro3 |
| Gene Name: | TYRO3 |
| Protein Full Name: | Tyrosine-protein kinase receptor TYRO3 |
| Alias: | BYK; DTK; EC 2.7.1.112; EC 2.7.10.1; RSE; SKY |
| Mass (Da): | 96905 |
| Number AA: | 890 |
| UniProt ID: | Q06418 |
| Locus ID: | 7301 |
| COSMIC ID: | TYRO3 |
| Gene location on chromosome: | 15q15.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19549 |
| Percent of cancer specimens with mutations: | 0.73 |
| Normal role description: | TYRO3 responds to TUB, TULP1, GAS6 and protein S as ligands and regulates cell survival, proliferation, immunoregulation, phagocytosis, cell migration, actin organization, spermatogenesis, platelet aggregation, clot stabilization, memory formation, circadian rhythm and synaptic plasticity. signalling transduction can occur via MAPK/ERK and Pi3K/AKT pathways. Overexpression by various cancers provide transformative ability and increased survival signals. |