Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZBTB16 |
| Gene Name: | ZBTB16 |
| Protein Full Name: | Zinc finger and BTB domain-containing protein 16 |
| Alias: | kruppel-like zinc finger; plzf; promyelocytic leukemia zinc finger; zbt16; zbtb16; zinc finger and BTB domain containing 16; zinc finger and BTB domain-containing 16; zinc finger protein 145 (PLZF); znf145 |
| Mass (Da): | 74274 |
| Number AA: | 673 |
| UniProt ID: | Q05516 |
| Locus ID: | 7704 |
| COSMIC ID: | ZBTB16 |
| Gene location on chromosome: | 11q23.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.03 |
| Deregulated in translocations: | t(11;17)(q23;q21): ZBTB16-RARA (acute promyelocytic leukaemia) |
| Normal role description: | Associated with myeloid differentiation. Represses transcription. Interacts with histone deacetylase and is involved in cell cycle progression. Probable component of an E3 ubiquitin-protein ligase complex. Translocations associated with acute promyelocytic leukemia. |