Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RhoA |
| Gene Name: | RHOA |
| Protein Full Name: | Transforming protein RhoA |
| Alias: | ARH12; ARHA; ARHA2; H12; ras gene family, member A; RHO12; RHOH12; Transforming protein RhoA |
| Mass (Da): | 21768 |
| Number AA: | 193 |
| UniProt ID: | P61586 |
| Locus ID: | 387 |
| COSMIC ID: | RHOA |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 21568 |
| Percent of cancer specimens with mutations: | 1.16 |
| Normal role description: | RHOA is a regulator of the signal transduction pathway that links plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. RHOA is involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell-cycle cytokinesis. Upregulation of this gene has been found in breast, colon, lung, esophageal, ovarian, stomach, and uterine tumors. |