Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HDAC4 |
| Gene Name: | HDAC4 |
| Protein Full Name: | Histone deacetylase 4 |
| Alias: | EC 3.5.1.98; HD4; Histone deacetylase 5; KIAA0288 |
| Mass (Da): | 119040 |
| Number AA: | 1084 |
| UniProt ID: | P56524 |
| Locus ID: | 9759 |
| COSMIC ID: | HDAC4 |
| Gene location on chromosome: | 2q37.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19791 |
| Percent of cancer specimens with mutations: | 1.14 |
| Normal role description: | HDAC4 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Involved in normal muscle development but role not described in cancer |