Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ASCL1 |
| Protein Full Name: | Achaete-scute homolog 1 |
| Mass (Da): | 25454 |
| Number AA: | 231 |
| UniProt ID: | P50553 |
| Locus ID: | 429 |
| Gene location on chromosome: | 12q23.2 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | Acts as a transcription activating protein and initiate transcription by binding to the E box (5'-CAANTG-3') of the DNA. Plays a role in neuronal differentiation, commitment and in the generation of olfactory and autonomic neurones. |