Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CENPF |
| Gene Name: | CENPF |
| Protein Full Name: | Centromere protein F |
| Alias: | AH; Cell-cycle-dependent 350K nuclear protein; CENF; CENP-F kinetochore; Centromere protein F, 350/400ka; Hcp-1; Kinetochore protein CENP-F; Mitosin |
| Mass (Da): | 367764 |
| Number AA: | 3210 |
| UniProt ID: | P49454 |
| Locus ID: | 1063 |
| COSMIC ID: | CENPF |
| Gene location on chromosome: | 1q32-q41 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19671 |
| Percent of cancer specimens with mutations: | 2.15 |
| Found in amplified chromosomal regions in human cancers: | Head and neck squamous cell carcinoma; atlasgeneticsoncology.org |
| Normal role description: | CENPF is a nuclear localized protein which associates with the centromere-kinetochore complex during mitosis. CENPF is thought to play a role in chromosome segregation and is a required component for kinetochore function. CENPF was found to recruit key components of the kinetochore complex including dynein, LIS1, NDE1 and NDEL1. The expression of CENPF is cell cycle dependent with the highest levels at G2 and M phase with rapid degradation after the completion of mitosis. Overexpression of CENPF has been shown to lead to chromosome instability and aneuploidy cells. CENPF overexpression has been implicated in neck squamous carcinomas, breast cancer, astrocytic gliomas and salivary gland tumours. |
| Commentary on involvement of protein in cancer: | Unknown percentage of head and neck cancers attributed to amplification |