Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Crk |
| Gene Name: | CRK |
| Protein Full Name: | Adapter molecule crk |
| Alias: | Adapter molecule crk; Crk-II; CRKO; P38; V-crk sarcoma virus CT10 oncogene |
| Mass (Da): | 33831 |
| Number AA: | 304 |
| UniProt ID: | P46108 |
| Locus ID: | 1398 |
| COSMIC ID: | CRK |
| Gene location on chromosome: | 17p13.3 |
| Cancer protein type: | ?TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.17 |
| Transduced into viral genome: | Avian sarcoma virus CT10 - Chicken |
| Normal role description: | CRK contains both an SH2 and SH3 domain and interacts with both receptor (ephrin, EGF, Insulin, PDGF) and non-receptor (SOS, MAP4K, ABL1) proteins. Role in oncogenesis unclear but frequent deletion of 17p13 locus in cancer implies potential TSP function within tyrosine kinase signalling pathways. |