Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Syk |
| Gene Name: | SYK |
| Protein Full Name: | Tyrosine-protein kinase SYK |
| Alias: | EC 2.7.10.2; Kinase Syk; KSYK; Spleen tyrosine kinase; SYK |
| Mass (Da): | 72066 |
| Number AA: | 635 |
| UniProt ID: | P43405 |
| Locus ID: | 6850 |
| COSMIC ID: | SYK |
| Gene location on chromosome: | 9q22 |
| Cancer protein type: | Both |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20892 |
| Percent of cancer specimens with mutations: | 0.67 |
| Deregulated in translocations: | ETV |
| Normal role description: | SYK is involved in BCR signal transduction. It can signal through PI3K or PLC depending on cell context and phoshrorylation state. SYK exprssion is lost in breast cancer and facilitate tumour growth and metastasis. A tranlocation with ETV6 mediates an overactive protein and dysregulated signal |