Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CD79B |
| Gene Name: | CD79B |
| Protein Full Name: | B-cell antigen receptor complex-associated protein |
| Alias: | B29; B-cell antigen receptor complex-associated protein beta; B-cell antigen receptor complex-associated protein beta-chain; B-cell-specific glycoprotein B29; CD79B; CD79b molecule, immunoglobulin-associated beta; IGB; Immunoglobulin-associated B29 |
| Mass (Da): | 26048 |
| Number AA: | 229 |
| UniProt ID: | P40259 |
| Locus ID: | 974 |
| COSMIC ID: | CD79B |
| Gene location on chromosome: | 17q23 |
| Number of cancer specimens: | 21641 |
| Percent of cancer specimens with mutations: | 0.79 |
| Commentary on involvement of protein in cancer: | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |