Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | THBS2 |
| Gene Name: | THBS2 |
| Protein Full Name: | Thrombospondin-2 |
| Alias: | tsp2 |
| Mass (Da): | 129991 |
| Number AA: | 1172 |
| UniProt ID: | P35442 |
| Locus ID: | 7058 |
| COSMIC ID: | THBS2 |
| Gene location on chromosome: | 6q27 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19634 |
| Percent of cancer specimens with mutations: | 1.71 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | THBS2 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It has been shown to be an inhibitor of tumour growth and angiogenesis. Loss of THBS2 is associated with tumour metastasis and neovascularization. It may play anti-angiogenic roles by acting as a ligand for CD36. |