Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | Tyk2 |
| Gene Name: | TYK2 |
| Protein Full Name: | Non-receptor tyrosine-protein kinase TYK2 |
| Alias: | EC 2.7.10.2; JTK1; Kinase Tyk2; Tyrosine kinase 2 |
| Mass (Da): | 133650 |
| Number AA: | 1187 |
| UniProt ID: | P29597 |
| Locus ID: | 7297 |
| COSMIC ID: | TYK2 |
| Gene location on chromosome: | 19p13.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20790 |
| Percent of cancer specimens with mutations: | 1.04 |
| Normal role description: | TYK2 is a tyrosine kinase and it is member of the the Janus kinases (JAKs) protein family. TYK2 is known to phosphorylates the interferon-alpha/beta receptor alpha chain. Missense mutations in this gene have been found in colon and ovarian tumors. |
| Commentary on involvement of protein in cancer: | Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. |