Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SDC1 |
| Gene Name: | SDC1 |
| Protein Full Name: | Syndecan-1 |
| Alias: | CD138 antigen; SDC; SYND1 |
| Mass (Da): | 32462 |
| Number AA: | 310 |
| UniProt ID: | P18827 |
| Locus ID: | 6382 |
| COSMIC ID: | SDC1 |
| Gene location on chromosome: | 2p24.1 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.29 |
| Normal role description: | Mediates cell-cell interactions, proliferation, migration, and signalling via proteoglycan heparan sulfate domains. Expression and shedding of this protein are upregulated in response to growth factor stimulation and also similarly upregulated in many cancer systems. SDC1 is required for Wnt-1 - induced mammary tumorigenesis but can also function as a tumour suppressor in different cancer types. Functions of surface SDC1 differ from SDC1 that is shed into the ECM. For example, cell surface SDC1 mediates adhesion of myeloma cells to collagen, inhibits invasion through collagen gels and also can mediate myeloma cell-cell adhesion. In contrast, shed syndecan-1 actively promotes myeloma tumour growth and metastasis. |