Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF2 |
| Gene Name: | ATF2 |
| Protein Full Name: | Cyclic AMP-dependent transcription factor ATF-2 |
| Alias: | Activating 2; Activating transcription factor 2; CAMP response element binding protein CRE- BP1; CREB2; CREBP1; CRE-BP1; Cyclic-AMP-dependent ATF-2; HB16; MXBP protein; TREB7 |
| Mass (Da): | 54537 |
| Number AA: | 505 |
| UniProt ID: | P15336 |
| Locus ID: | 1386 |
| COSMIC ID: | ATF2 |
| Gene location on chromosome: | 2q31.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20120 |
| Percent of cancer specimens with mutations: | 0.42 |
| Deregulated in translocations: | Translocation t(2;12)( q31.1;q13) forming the EWS-ATF2 fusion protein that may define a subset of Clear Cell Sarcoma tumors. |
| Normal role description: | ATF2 is a cAMP response element (CRE) binding protein (BP) -- or 'CREB'. ATF2 is known to form heterodimers with c-Jun therby stimulating CRE-dependant transcription, which includes transcription of such pro-growth as c-Myc and cyclin D. There ATF2, if upregulated in activity via mutation, could act as an oncoprotein. Chromosomal rearrangemnts of this gene have lead to a fusion protein that is a hall-mark of a subset of Clear Cell Sarcoma. |
| Commentary on involvement of protein in cancer: | This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2/JUN complex.Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity. |